primate genetic test data sheet
detection of Mu opioid receptor polymorphisms in macaques
receptor is an important component of neurobiological systems,
most notably those associated with sensory response to pain,
pleasure, stress, and the hypothalamic-pituitary-adrenal (HPA)
axis. The receptor is a G-protein coupled receptor and is
located primarily in neurons. It is the target binding receptor
for many opiate drugs, and is associated with the addictive
processes of cocaine, alcohol and nicotine.
behavioral studies in rhesus macaques have shown that genetic
variations in the mu-opioid receptor can affect the attachment
behavior of monkeys (Barr et al., 2008). A DNA polymorphism,
C77G, is especially associated with such behavior. The
polymorphism causes a greater binding affinity for
beta-endorphin, which is an endogenous opioid peptide
neurotransmitter found in the neurons of both central and
peripheral nervous systems. Since abnormal levels of
beta-endorphin may be related to psychological disorders,
intense effort has been devoted to designing drugs that could
effectively target this mu-opioid receptor.
are widely used as models for behavioral and drug research;
prescreening for this polymorphism is important in qualifying
the monkeys for preclinical trials. Molecular detection of this
polymorphism is a rapid and accurate way to identify the
genotype of the monkeys.
Help confirm macaque genotype
Prequalify monkeys for preclinical trials
Barr, C.S., Schwandt, M.L., Lindell, S.G., Dee Higley, J.,
Maestripieri, D., Goldman, D., Suomi, S. J. and Heiling, M.
(2008) Variation at the mu-opioid receptor gene (OPRM1)
influences attachment behavior in infant primates. Proc. Natl.
Acad. Sci. 105: 5277-5281.
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