Zoologix performs primate infectious disease tests by PCR for...

Adenoviruses

African green monkey endogenous virus

Aspergillus

B virus

Babesia

Baboon endogenous virus

Baylisascaris procyonis

Borrelia burgdorferi

Burkholderia

Campylobacter

Chagas' disease

Chikungunya virus

Chlamydia pneumoniae

Chlamydophila trachomatis

Clostridium

Coccidioides

Cronobacter sakazakii

Cryptosporidium

Cynomolgus polyomavirus

Cytomegalovirus, baboon

Cytomegalovirus, chimpanzee

Cytomegalovirus, human

Cytomegalovirus, macaque

Cytomegalovirus, simian

Dengue

E. coli O157:H7

E. coli panel

Encephalitis, Japanese

Encephalitis, St. Louis

Encephalomyocarditis (EMCV)

Entamoeba species

Enterovirus

Epstein-Barr virus

Giardia

Gibbon ape leukemia

Helicobacter

Hepatitis A virus

Hepatitis B virus

Hepatitis C virus

Herpes ateles

Herpes B virus

Herpes simplex type 1

Herpes simplex type 2

Herpes tamarinus

Herpesvirus ateles

Herpesvirus papio 1 & 2

Herpesvirus saimiri

Human adenoviruses

Human herpesviruses types 6, 7 & 8

Human immunodeficiency virus types 1 & 2

Human T cell lymphotropic virus

Human Varicella-Zoster

Influenza type A

Klebsiella

Lawsonia intracellularis

Leishmania

Leptospira

Lyme disease

Lymphocryptovirus

Malaria

Measles

Monkeypox

Mycobacteria

Mycoplasma

Neisseria gonorhoeae

Neisseria meningitidis

Papillomavirus

Parvoviruses

Plasmodium species

Reovirus screen

Rhesus rhadinovirus

Rotavirus

Salmonella

Shigella and enteroinvasive E. coli

Simian agent 6 (SA6)

Simian agent 8 (SA8)

Simian foamy virus (SFV)

Simian hemorrhagic fever (SHFV)

Simian immunodeficiency virus (SIV)

Simian parainfluenza virus

Simian retrovirus (SRV)

Simian sarcoma virus

Simian T-cell leukemia (STLV) types 1 & 2

Simian T-cell leukemia (STLV) type 3

Simian Varicella-Zoster

Squirrel monkey retrovirus

Streptococcus pneumoniae

Streptococcus pyogenes

SV40

SV5

Syphilis

Tetanus

Toxoplasma gondii

Treponema

Trichomonas/
Tritrichomonas

Trypanosoma cruzi

Tuberculosis

Ureaplasma

Valley fever

West Nile virus (WNV)

Yaws

Yellow fever

Yersinia pestis

Yersinia pseudotuberculosis

Zika virus

* * *

Genetic tests for...

A/B/AB blood type in macaques

Cynomolgus genotyping

Fetal sexing

Mamu-6 in macaques

Mamu-7 in macaques

CYP2C76 c.449TG>A
in macaques

Mu opioid receptor
in macaques

smCCR5Δ24
in sooty mangabeys

...and more - contact Zoologix with your genetic testing requirements


Primate genetics: Mu Opioid Receptor PCR test for macaques

primate genetic test data sheet

PCR detection of Mu opioid receptor polymorphisms in macaques

Test code:
GP002

 

The mu-opioid receptor is an important component of neurobiological systems, most notably those associated with sensory response to pain, pleasure, stress, and the hypothalamic-pituitary-adrenal (HPA) axis. The receptor is a G-protein coupled receptor and is located primarily in neurons. It is the target binding receptor for many opiate drugs, and is associated with the addictive processes of cocaine, alcohol and nicotine.

Recent behavioral studies in rhesus macaques have shown that genetic variations in the mu-opioid receptor can affect the attachment behavior of monkeys (Barr et al., 2008). A DNA polymorphism, C77G, is especially associated with such behavior. The polymorphism causes a greater binding affinity for beta-endorphin, which is an endogenous opioid peptide neurotransmitter found in the neurons of both central and peripheral nervous systems. Since abnormal levels of beta-endorphin may be related to psychological disorders, intense effort has been devoted to designing drugs that could effectively target this mu-opioid receptor.

Macaques are widely used as models for behavioral and drug research; prescreening for this polymorphism is important in qualifying the monkeys for preclinical trials. Molecular detection of this polymorphism is a rapid and accurate way to identify the genotype of the monkeys.

Utilities:

  • Help confirm macaque genotype
  • Prequalify monkeys for preclinical trials

References:
Barr, C.S., Schwandt, M.L., Lindell, S.G., Dee Higley, J., Maestripieri, D., Goldman, D., Suomi, S. J. and Heiling, M. (2008) Variation at the mu-opioid receptor gene (OPRM1) influences attachment behavior in infant primates. Proc. Natl. Acad. Sci. 105: 5277-5281.

Specimen requirement: 0.2 ml whole blood in EDTA (purple top) tube, or buccal swab, or 0.2 ml fresh or frozen tissue.

Contact Zoologix if advice is needed to determine an appropriate specimen type for a specific diagnostic application. For specimen types not listed here, please contact Zoologix to confirm specimen acceptability and shipping instructions.

For all specimen types, if there will be a delay in shipping, or during very warm weather, refrigerate specimens until shipped and ship with a cold pack unless more stringent shipping requirements are specified. Frozen specimens should be shipped so as to remain frozen in transit. See shipping instructions for more information.

Turnaround time: 3 business days

Methodology: PCR

©2003-2024 Zoologix, Inc. • Email Zoologix • Phone (818) 717-8880