Need serology?
Yes, we're still the PCR experts. But Zoologix also performs ELISA antibody tests for...

SRV
Herpes B
SIV
STLV
Measles
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* * *

Zoologix performs primate infectious disease tests by PCR for...

B virus

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Borrelia burgdorferi

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Chlamydophila trachomatis

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Reovirus screen

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Tritrichomonas

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* * *

Genetic tests for...

A/B/AB blood type in macaques

Fetal sexing

Mamu-6 in macaques

Mamu-7 in macaques

CYP2C76 c.449TG>A
in macaques

Mu opioid receptor
in macaques

smCCR5Δ24
in sooty mangabeys

...and more - contact Zoologix with your genetic testing requirements


Primate genetics: Mu Opioid Receptor PCR test for macaques

primate genetic test data sheet

PCR detection of Mu opioid receptor polymorphisms in macaques

Test code:
GP002

 

The mu-opioid receptor is an important component of neurobiological systems, most notably those associated with sensory response to pain, pleasure, stress, and the hypothalamic-pituitary-adrenal (HPA) axis. The receptor is a G-protein coupled receptor and is located primarily in neurons. It is the target binding receptor for many opiate drugs, and is associated with the addictive processes of cocaine, alcohol and nicotine.

Recent behavioral studies in rhesus macaques have shown that genetic variations in the mu-opioid receptor can affect the attachment behavior of monkeys (Barr et al., 2008). A DNA polymorphism, C77G, is especially associated with such behavior. The polymorphism causes a greater binding affinity for beta-endorphin, which is an endogenous opioid peptide neurotransmitter found in the neurons of both central and peripheral nervous systems. Since abnormal levels of beta-endorphin may be related to psychological disorders, intense effort has been devoted to designing drugs that could effectively target this mu-opioid receptor.

Macaques are widely used as models for behavioral and drug research; prescreening for this polymorphism is important in qualifying the monkeys for preclinical trials. Molecular detection of this polymorphism is a rapid and accurate way to identify the genotype of the monkeys.

Utilities:

  • Help confirm macaque genotype
  • Prequalify monkeys for preclinical trials

References:
Barr, C.S., Schwandt, M.L., Lindell, S.G., Dee Higley, J., Maestripieri, D., Goldman, D., Suomi, S. J. and Heiling, M. (2008) Variation at the mu-opioid receptor gene (OPRM1) influences attachment behavior in infant primates. Proc. Natl. Acad. Sci. 105: 5277-5281.

Specimen requirement: Buccal swab, or 0.2 ml whole blood in EDTA (purple top) or ACD (yellow top) tube.

For specimen types other than those listed here, please call to confirm specimen acceptability and shipping instructions.

For all specimen types, if there will be a delay in shipping, or during very warm weather, refrigerate specimens until shipped and ship with a cold pack unless more stringent shipping requirements are specified. Frozen specimens should be shipped so as to remain frozen in transit. See shipping instructions for more information.

Turnaround time: 2 business days

Methodology: PCR

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