Need serology?
Yes, we're still the PCR experts. But Zoologix also performs ELISA antibody tests for...

SRV
Herpes B
SIV
STLV
Measles
Hepatitis A
Hepatitis B
Hepatitis C

* * *

Zoologix performs primate infectious disease tests by PCR for...

Adenoviruses

Aspergillus

B virus

Babesia

Baboon endogenous virus

Baylisascaris procyonis

Borrelia burgdorferi

Campylobacter

Chagas' disease

Chikungunya virus

Chlamydia pneumoniae

Chlamydophila trachomatis

Clostridium

Cronobacter sakazakii

Cryptosporidium

Cytomegalovirus, baboon

Cytomegalovirus, chimpanzee

Cytomegalovirus, human

Cytomegalovirus, macaque

Cytomegalovirus, simian

Dengue

E. coli O157:H7

E. coli panel

Encephalitis, Japanese

Encephalitis, St. Louis

Encephalomyocarditis (EMCV)

Entamoeba species

Enterovirus

Epstein-Barr virus

Giardia

Gibbon ape leukemia

Helicobacter

Hepatitis A virus

Hepatitis B virus

Hepatitis C virus

Herpes ateles

Herpes B virus

Herpes simplex type 1

Herpes simplex type 2

Herpes tamarinus

Herpesvirus ateles

Herpesvirus papio 1 & 2

Herpesvirus saimiri

Human adenoviruses

Human herpesviruses types 6, 7 & 8

Human immunodeficiency virus types 1 & 2

Human T cell lymphotropic virus

Human Varicella-Zoster

Influenza

Klebsiella

Lawsonia intracellularis

Leptospira

Lyme disease

Lymphocryptovirus

Malaria

Measles

Monkeypox

Monkey parvoviruses

Mycobacteria

Mycoplasma

Neisseria gonorhoeae

Neisseria meningitidis

Papillomavirus

Plasmodium species

Reovirus screen

Rhesus rhadinovirus

Rotavirus

Salmonella

Shigella and enteroinvasive E. coli

Simian agent 6 (SA6)

Simian agent 8 (SA8)

Simian foamy virus (SFV)

Simian hemorrhagic fever (SHFV)

Simian immunodeficiency virus (SIV)

Simian parainfluenza virus

Simian retrovirus (SRV)

Simian sarcoma virus

Simian T-cell leukemia (STLV) types 1 & 2

Simian T-cell leukemia (STLV) type 3

Simian Varicella-Zoster

Squirrel monkey retrovirus

Streptococcus pneumoniae

Streptococcus pyogenes

SV40

SV5

Toxoplasma gondii

Treponema pallidum

Trichomonas/
Tritrichomonas

Trypanosoma cruzi

Tuberculosis

Ureaplasma

West Nile virus (WNV)

Yellow fever

Yersinia pestis

Yersinia pseudotuberculosis

* * *

Genetic tests for...

A/B/AB blood type in macaques

Fetal sexing

Mamu-6 in macaques

Mamu-7 in macaques

CYP2C76 c.449TG>A
in macaques

Mu opioid receptor
in macaques

smCCR5Δ24
in sooty mangabeys

...and more - contact Zoologix with your genetic testing requirements


Macaque cytomegalovirus PCR test
primate assay data sheet

Macaque cytomegalovirus

Test code:
S0018 - Ultrasensitive qualitative detection of cytomegalovirus in rhesus and cynomolgus macaques by real time polymerase chain reaction

 

Cytomegalovirus in macaques exhibits strong parallels with human CMV (HCMV) in terms of nucleic and amino acid identities, natural history, and mechanisms of persistence and pathogenesis in macaques, its natural host. CMV is ubiquitous in captive rhesus macaques, with infection rates of greater than 90% by the first year of life. Cytomegalovirus infections in macaques share several features with HCMV infections. The majority of macaque CMV infections are subclinical, and healthy adults tend to shed virus in their urine, saliva, semen, cervical secretions, and breast milk for years. It was recently estimated that approximately 90% of adult macaques at the California National Primate Research Center are infected with cytomegalovirus. This infection rate is similar to those observed in other captive populations. While programs are in place in a number of primate centers and breeding facilities to expand the number of specific-pathogen-free (SPF) animals for this virus, demand for rhesus macaques will exceed the supply of SPF animals for the foreseeable future.

Infection of macaques with macaque CMV provides an excellent model for HCMV persistence and pathogenesis. HCMV is the most common congenital infection in the world and a significant cause of morbidity and mortality in immunocompromised patients. Determination of the frequency and magnitude of CMV shedding in macaques would expand our understanding of the natural history of this infection.

Although virus isolation can be used to diagnose CMV infection, a long incubation period is required to obtain results. Viral culture also increases the potential risk of laboratory personnel contacting this virus. Furthermore, viral culture is less sensitive, reliable and specific than newer polymerase chain reaction (PCR)-based techniques.

Utilities:

  • Help confirm the disease causing agent
  • Help ensure that animal colonies are free of CMV
  • Early prevention of spread of this virus among a colony
  • Minimize personnel exposure to this virus
  • Safety monitoring of biological products and vaccines that derive from monkeys

Specimen requirement: 0.2 ml whole blood in EDTA (purple top) or ACD (yellow top) tube, or 0.2 ml serum or plasma.

For specimen types other than those listed here, please call to confirm specimen acceptability and shipping instructions.

For all specimen types, if there will be a delay in shipping, or during very warm weather, refrigerate specimens until shipped and ship with a cold pack unless more stringent shipping requirements are specified. Frozen specimens should be shipped so as to remain frozen in transit. See shipping instructions for more information.

Turnaround time: 2 business days

Methodologies: Qualitative real time PCR

Normal range: Nondetected

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