Zoologix performs primate infectious disease tests by PCR for...


African green monkey endogenous virus


B virus


Baboon endogenous virus

Baylisascaris procyonis

Borrelia burgdorferi



Chagas' disease

Chikungunya virus

Chlamydia pneumoniae

Chlamydophila trachomatis



Cronobacter sakazakii


Cytomegalovirus, baboon

Cytomegalovirus, chimpanzee

Cytomegalovirus, human

Cytomegalovirus, macaque

Cytomegalovirus, simian


E. coli O157:H7

E. coli panel

Encephalitis, Japanese

Encephalitis, St. Louis

Encephalomyocarditis (EMCV)

Entamoeba species


Epstein-Barr virus


Gibbon ape leukemia


Hepatitis A virus

Hepatitis B virus

Hepatitis C virus

Herpes ateles

Herpes B virus

Herpes simplex type 1

Herpes simplex type 2

Herpes tamarinus

Herpesvirus ateles

Herpesvirus papio 1 & 2

Herpesvirus saimiri

Human adenoviruses

Human herpesviruses types 6, 7 & 8

Human immunodeficiency virus types 1 & 2

Human T cell lymphotropic virus

Human Varicella-Zoster



Lawsonia intracellularis



Lyme disease







Neisseria gonorhoeae

Neisseria meningitidis



Plasmodium species

Reovirus screen

Rhesus rhadinovirus



Shigella and enteroinvasive E. coli

Simian agent 6 (SA6)

Simian agent 8 (SA8)

Simian foamy virus (SFV)

Simian hemorrhagic fever (SHFV)

Simian immunodeficiency virus (SIV)

Simian parainfluenza virus

Simian retrovirus (SRV)

Simian sarcoma virus

Simian T-cell leukemia (STLV) types 1 & 2

Simian T-cell leukemia (STLV) type 3

Simian Varicella-Zoster

Squirrel monkey retrovirus

Streptococcus pneumoniae

Streptococcus pyogenes



Toxoplasma gondii

Treponema pallidum


Trypanosoma cruzi



Valley fever

West Nile virus (WNV)

Yellow fever

Yersinia pestis

Yersinia pseudotuberculosis

Zika virus

* * *

Genetic tests for...

A/B/AB blood type in macaques

Cynomolgus genotyping

Fetal sexing

Mamu-6 in macaques

Mamu-7 in macaques

CYP2C76 c.449TG>A
in macaques

Mu opioid receptor
in macaques

in sooty mangabeys

...and more - contact Zoologix with your genetic testing requirements

Hepatitis C PCR test for primates
primate assay data sheet

Hepatitis C virus (HCV) by PCR

Test codes:

S0045 - Ultrasensitive qualitative detection of hepatitis C virus by reverse transcription coupled real time polymerase chain reaction

(A0009 - Detection of total antibodies to hepatitis C virus in nonhuman primates)


Hepatitis C virus (HCV) is member of the Flaviviridae family and is the major causative agent of parenterally transmitted non-A, non-B hepatitis worldwide. Genetic analysis of this virus led to the discovery of six major genetic groups (genotypes 1-6) and multiple minor genetic groups (subtypes 1a, 1b, 2a, 2b, etc.). To date, chimpanzees represent the only appropriate animal model for studying HCV infection, as they are easily infected with human hepatitis C virus and develop acute or chronic hepatitis (Farci and Purcell, 1993; Schlauder et al., 1991). HCV infection in other wild or captive non-human primates is still controversial and the possibility of such infection cannot be ruled out (Korzaya et al., 2002; Peli et al., 2002).

Diagnostic tests currently available either detect direct antibodies to HCV (anti-HCV) or HCV RNA. Anti-HCV indicates prior exposure to HCV but does not distinguish between cleared and active infection. An additional immunoassay such as RIBA may confirm the status of infection, but such immunoassays have a high indeterminate rate. Detection of HCV RNA by reverse transcription PCR offers a more rapid, sensitive and specific method for diagnosis of active HCV infection.


  • Help confirm the disease causing agent
  • Help ensure that animal colonies are free of Hepatitis C
  • Early prevention of spread of this virus among a colony
  • Minimize personnel exposure to this virus
  • Safety monitoring of biological products and vaccines that derive from primates

Farci, P. and Purcell, R.H. (1993) Hepatitis C virus: natural history and experimental models. In: Zuckerman AJ, Thomas HC, eds. Viral hepatitis: scientific basis and clinical management. Edinburg, UK: Churchill Livingstone, 241-267.
Korzaya, L.I., Lapin, B.A., Keburiya, V.V. and Chikobava, M.G. (2002) Spontaneous infection of lower primates with hepatitis C virus. Bull Exp Biol Med. 133:178-181.
Peli, A., Scagliarini, A., Cinotti, S. and Martinelli, G.N. (2002) Seropositivity to HCV in Macaca fascicularis. New Microbiol. 25:231-234.
Schlauder, G.G., Leverenz, G.J., Amann, C.W., Lesniewski, R.R. and Peterson, D.A. (1991) Detection of the hepatitis C virus genome in acute and chronic experimental infection in chimpanzees. J Clin Microbiol 29: 2175-2179.

Specimen requirement: 0.2 ml whole blood in EDTA (purple top) or ACD (yellow top) tube, or 0.2 ml plasma or serum, or 0.2 ml fresh or frozen liver tissue.

Contact Zoologix if advice is needed to determine an appropriate specimen type for a specific diagnostic application. For specimen types not listed here, please contact Zoologix to confirm specimen acceptability and shipping instructions.

For all specimen types, if there will be a delay in shipping, or during very warm weather, refrigerate specimens until shipped and ship with a cold pack unless more stringent shipping requirements are specified. Frozen specimens should be shipped so as to remain frozen in transit. See shipping instructions for more information.

Turnaround time: 2 business days

Methodology: Qualitative reverse transcription coupled real time PCR

Normal range: Nondetected

2003-2018 Zoologix, Inc. • Email Zoologix • Phone (818) 717-8880