Need serology?
Yes, we're still the PCR experts. But Zoologix also performs ELISA antibody tests for...

SRV
Herpes B
SIV
STLV
Measles
Hepatitis A
Hepatitis B
Hepatitis C

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Zoologix performs primate infectious disease tests by PCR for...

Adenoviruses

Aspergillus

B virus

Babesia

Baboon endogenous virus

Baylisascaris procyonis

Borrelia burgdorferi

Campylobacter

Chagas' disease

Chikungunya virus

Chlamydia pneumoniae

Chlamydophila trachomatis

Clostridium

Cronobacter sakazakii

Cryptosporidium

Cytomegalovirus, baboon

Cytomegalovirus, chimpanzee

Cytomegalovirus, human

Cytomegalovirus, macaque

Cytomegalovirus, simian

Dengue

E. coli O157:H7

E. coli panel

Encephalitis, Japanese

Encephalitis, St. Louis

Encephalomyocarditis (EMCV)

Entamoeba species

Enterovirus

Epstein-Barr virus

Giardia

Gibbon ape leukemia

Helicobacter

Hepatitis A virus

Hepatitis B virus

Hepatitis C virus

Herpes ateles

Herpes B virus

Herpes simplex type 1

Herpes simplex type 2

Herpes tamarinus

Herpesvirus ateles

Herpesvirus papio 1 & 2

Herpesvirus saimiri

Human adenoviruses

Human herpesviruses types 6, 7 & 8

Human immunodeficiency virus types 1 & 2

Human T cell lymphotropic virus

Human Varicella-Zoster

Influenza

Klebsiella

Lawsonia intracellularis

Leptospira

Lyme disease

Lymphocryptovirus

Malaria

Measles

Monkeypox

Monkey parvoviruses

Mycobacteria

Mycoplasma

Neisseria gonorhoeae

Neisseria meningitidis

Papillomavirus

Plasmodium species

Reovirus screen

Rhesus rhadinovirus

Rotavirus

Salmonella

Shigella and enteroinvasive E. coli

Simian agent 6 (SA6)

Simian agent 8 (SA8)

Simian foamy virus (SFV)

Simian hemorrhagic fever (SHFV)

Simian immunodeficiency virus (SIV)

Simian parainfluenza virus

Simian retrovirus (SRV)

Simian sarcoma virus

Simian T-cell leukemia (STLV) types 1 & 2

Simian T-cell leukemia (STLV) type 3

Simian Varicella-Zoster

Squirrel monkey retrovirus

Streptococcus pneumoniae

Streptococcus pyogenes

SV40

SV5

Toxoplasma gondii

Treponema pallidum

Trichomonas/
Tritrichomonas

Trypanosoma cruzi

Tuberculosis

Ureaplasma

West Nile virus (WNV)

Yellow fever

Yersinia pestis

Yersinia pseudotuberculosis

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Genetic tests for...

A/B/AB blood type in macaques

Fetal sexing

Mamu-6 in macaques

Mamu-7 in macaques

CYP2C76 c.449TG>A
in macaques

Mu opioid receptor
in macaques

smCCR5Δ24
in sooty mangabeys

...and more - contact Zoologix with your genetic testing requirements


PCR tests for human herpesviruses 6, 7 and 8 for primates
primate assay data sheet

Human herpesviruses 6, 7 and 8

Test codes:
S0043
- Ultrasensitive qualitative detection of human herpesvirus type 6 by real time PCR. This assay detects but does not differentiate subtypes 6A and 6B.
S0044 - Ultrasensitive qualitative detection of human herpesvirus type 7 by real time PCR
S0049 - Ultrasensitive qualitative detection of human herpesvirus type 8 by real time PCR

Human herpesvirus 6 (HHV-6) is double-stranded DNA virus belonging to the betaherpesvirinae subfamily. There are two major subtypes of this virus: human herpesvirus 6A (HHV-6A) and human herpesvirus 6B (HHV-6B). Human is the primary host of this virus.

HHV-6A has been described as more neurovirulent, and is more frequently found in patients with neuroinflammatory diseases such as multiple sclerosis.

HHV-6B primary infection is the cause of the common childhood disease, exanthem subitum (also known as roseola infantum or sixth disease). Additionally, HHV-6B reactivation is common in transplant recipients and immunocompromised patients, and can cause clinical manifestations including encephalitis, bone marrow suppression and pneumonitis.

Cynomolgus monkeys and African green monkeys can be infected experimentally with HHV-6, and thus they are used as animal models to study the infection.

Serological diagnosis of HHV-6 active infection is not very useful because most people have had prior exposure to the virus. However, molecular detection by PCR provides rapid, highly sensitive and highly specific detection of the presence of the virus.

Human herpesvirus 8 (HHV-8), also known as Kaposi’s sarcoma-associated herpesvirus (KSHV), is a double-stranded DNA virus belonging to the Herpesviridae family. Infection by the virus can cause Kaposi’s sarcoma (KS), primary effusion lymphoma (PEL) and a subset of Multicentric Castleman’s disease (MCD). HHV-8 can infect B cells, endothelial cells, CD34+ cells, and monocytic cells.

Transmission of HHV-8 can occur through sexual contact or non-sexual routes. Seroprevalence in the United States in the general population is 5-10%, but is higher in certain groups, such as homosexual men, and in other geographic regions such as the Mediterranean, South America and Africa.

Viruses related to HHV-8 have been detected in several primate species. Sequence analysis of HHV-8 related viral DNA isolated from these monkeys showed ~97% homology to HHV-8, suggesting that this virus may cross-infect between species (Colombini-Hatch et al, 1999).

Serological detection of HHV-8 antibody can be used to identify individuals exposed to the virus. Molecular detection by PCR is used to confirm the presence of the virus in samples from animals suspected to be infected.

Utilities:

  • Help confirm the disease causing agent
  • Help ensure that animal colonies are free of these viruses
  • Early prevention of spread of these viruses among a colony
  • Minimize personnel exposure to these viruses
  • Safety monitoring of biological products and vaccines that derive from primates

Specimen requirement: 0.2 ml whole blood in EDTA (purple top) or ACD (yellow top) tube.

For specimen types other than those listed here, please call to confirm specimen acceptability and shipping instructions.

For all specimen types, if there will be a delay in shipping, or during very warm weather, refrigerate specimens until shipped and ship with a cold pack unless more stringent shipping requirements are specified. Frozen specimens should be shipped so as to remain frozen in transit. See shipping instructions for more information.

Turnaround time: 2 business days

Methodology: Qualitative real time PCR

Normal range: Nondetected

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