We've added new PCR tests for swine and bovine diseases -- see our menu for a complete listing.

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Zoologix performs avian and livestock PCR tests for...

Actinobacillus pleuropneumoniae

African swine fever

Akabane virus

Alcelaphine herpesvirus

AMPKγ3R200Q mutation in pigs

Anaplasma phagocytophilum

Aspergillus fumigatus

Aspergillus species


Aujeszky's disease

Avian adenovirus

Avian herpes

Avian influenza

Avian polyomavirus

Avian reovirus

Avibacterium paragallinarum

Baylisascaris procyonis

Blood typing for swine

Bluetongue virus

Bordetella avium

Borna virus

Bovine adenovirus

Bovine endogenous retrovirus

Bovine enterovirus

Bovine ephemeral fever virus

Bovine herpesvirus 1

Bovine herpesvirus 2

Bovine herpesvirus 4

Bovine leukemia virus

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Bovine papular stomatitis virus

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Bovine respiratory syncytial virus

Bovine rhinoviruses

Bovine viral diarrhea type 1

Brachyspira pilosicoli


Cache Valley virus




Caprine arthritis-encephalitis (CAE) virus

Chlamydia/Chlamydophila genus

Chlamydophila psittaci

Classical swine fever






Coxiella burnetii



Ebola Reston

E. coli O157:h7



Enteric E. coli panel

Erysipelothrix rhusiopathiae

Foot and mouth disease

Fowl adenovirus


Fusobacterium necrophorum

Hepatitis E

Herpes, avian


Infectious bronchitis

Infectious bursal disease

Infectious coryza

Infectious laryngotracheitis

Influenza type A

Jaagsiekte sheep retrovirus (JSRV)

Japanese encephalitis

Jena virus

Johne's disease

Lawsonia intracellularis


Lumpy skin disease virus


Malignant catarrhal fever (MCF)


Mycobacterium avium and other Mycobacteria

Mycoplasma species

Mycoplasma suis

Newcastle disease virus

Nipah virus

Ornithobacterium rhinotracheale

Ovine herpesvirus 2

Pacheco's disease (psittacid herpesviruses)

Peste des petits ruminants virus (PPRV)

Pigeon circovirus

Plasmodium species

Porcine adenovirus

Porcine circovirus 1

Porcine circovirus 2

Porcine cytomegalovirus

Porcine endogenous retrovirus (PERV)

Porcine enterovirus

Porcine epidemic diarrhea virus

Porcine hemagglutinating encephalomyelitis

Porcine hemorrhagic enteropathy

Porcine intestinal adenomatosis

Porcine lymphotropic herpesvirus

Porcine parvovirus

Porcine reproductive & respiratory syndrome (PRRS) virus

Porcine respiratory coronavirus (PRCV)

Porcine transmissible gastroenteritis virus (TGEV)

Poultry respiratory panel



Psittacine beak and feather disease

Psittacine herpes

Q fever



Rift Valley fever virus

Rinderpest virus

RyR1 R615C mutation in pigs


Staphylococcus xylosus

St. Louis encephalitis



Swine vesicular disease

Taenia solium

Teschovirus (Teschen-Talfan disease)

Tickborne encephalitis virus

Trichinella spiralis



Valley fever

Vesicular exanthema of swine

Vesicular stomatitis

Wesselsbron virus

West Nile virus

Yersinia enterocolitica

Yersinia pseudotuberculosis

...and more -- see the avian & livestock test menu for a complete listing of avian and livestock assays.

Alcelaphine virus PCR test
avian & livestock assay data sheet

Alcelaphine herpesvirus type 1 (malignant catarrhal fever)

Test code: S0218 - Ultrasensitive detection of alcelaphine herpesvirus 1 by real time PCR

Malignant catarrhal fever (MCF) is an infectious viral disease that has a wide clinical spectrum depending on the species of animal being infected. The disease mainly affects ruminants, and rarely, swine. The virus infects domestic cattle, water buffalo, Bali cattle (banteng), American bison, and deer. In addition to these farmed animals, infection has been described in a variety of captive ruminants in mixed zoo collections.

Several members of a group of closely related ruminant gammaherpesviruses of the Rhadinovirus genus are responsible for causing MCF. This group of ruminant rhadinoviruses currently comprises approximately 10 known members but only a few are known to be pathogenic under natural conditions. The principal carriers and their viruses are sheep (ovine herpesvirus 2), wildebeest (alcelaphine herpesvirus 1), and goats (caprine herpesvirus 2). Another strain of unidentified origin has also been reported to cause MCF in white-tailed deer. Virtually all clinical cases of MCF are caused by the sheep or wildebeest strains.

In bison and some deer, MCF is acute and highly lethal, capable of infecting whole herds; however, in cattle the disease is generally seen sporadically and usually does not spread through a herd. Although infection is usually fatal, recovery has been documented in some infected animals, a few of these having developed only mild or subclinical symptoms. Occasionally, MCR presents only as chronic alopecia and weight loss.

Transmission of the virus can be through direct contact with nasal secretions from infected animals or through airborne route. Infection is lifelong in animals that survive, and recrudescence of latent infections is possible.

A preferred method for clinical diagnosis of alcelaphine herpesvirus 1 infection is molecular detection of viral DNA by PCR (Traul et al., 2005).


  • Help confirm the disease causing agent
  • Shorten the time required to confirm a clinical diagnosis of Alcelaphine herpesvirus-1 infection
  • Help ensure that animal herds and populations are free of MCF
  • Early prevention of spread of the virus among animals
  • Minimize human exposure to the virus
  • Safety monitoring of biological products that derive from animals

Traul, D.L., Elias, S., Taus, N.S., Herrmann, L.M., Oaks, J.L., Li, H. (2005) A real-time PCR assay for measuring alcelaphine herpesvirus-1 DNA. J. Virol. Methods. 129:186-190.

Specimen requirements: 0.2 ml whole blood in EDTA (purple top) tube, or nasal or throat swab, or 0.2 ml fresh, frozen or fixed tissue (kidney, intestinal wall, lymph node or brain).

Contact Zoologix if advice is needed to determine an appropriate specimen type for a specific diagnostic application. For specimen types not listed here, please contact Zoologix to confirm specimen acceptability and shipping instructions.

For all specimen types, if there will be a delay in shipping, or during very warm weather, refrigerate specimens until shipped and ship with a cold pack unless more stringent shipping requirements are specified. Frozen specimens should be shipped so as to remain frozen in transit. See shipping instructions for more information.

Turnaround time: 2 business days

Methodology: Qualitative reverse transcription coupled real time PCR

Normal range: Nondetected

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