Screening your mice? Try our Mouse Essentials PCR Panel. All the most important mouse colony screening tests, all by expert real time PCR...

...or how about our new Mouse PCR Minipanel - PCR tests for only the most common mouse pathogens - for economical colony screening...

...and don't forget our Mouse Fecal PCR Panel - includes 9 important fecal pathogens.

And... just for rabbits: our new Rabbit Fecal PCR Panel tests for 3 common causes of GI problems in rabbits.

For wild rodent infestations, remediation and environmental monitoring, use our Rodent Infestation PCR Panel

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Zoologix also performs rodent and rabbit PCR tests for...

Aspiculuris tetraptera


BXV-1 virus



Clostridium piliforme


E. coli (enteroinvasive)



Encephalitozoon cuniculi


Francisella tularensis

Fur mites



Human adenoviruses

Klebsiella pneumoniae

K virus

Lactate dehydrogenase-elevating virus


Lymphocytic choriomeningitis virus (LCMV)


Mouse adenoviruses

Mouse cytomegaloviruses

Mouse hepatitis virus (MHV)

Mouse kidney parvovirus (MKV or MKPV)

Mouse minute virus (MMV)

Mouse norovirus (MNV)

Mouse parvovirus (MPV)

Mouse polyoma virus (POLY)

Mousepox virus (aka ectromelia virus, EV or ECTRO)

Mouse rotavirus

Mycoplasma pulmonis

Mycoplasma screen



Pneumocystis carinii

Pneumonia virus of mice (PVM)

Rabbit coronavirus

Rabbit fibroma virus

Rabbit hemorrhagic disease virus

Rat bite fever

Rat coronavirus

Reovirus screen

Reovirus type 3 (REO3)



Sendai virus (SEND)

Seoul virus


Sialodacryoadenitis virus (SDAV)

Streptobacillus moniliformis

Streptococcus pneumoniae

Syphacia muris

Syphacia obvelata

Theiler's murine encephalomyelitis virus (TMEV)

Tickborne encephalitis virus

Treponema cuniculi/ paraluiscuniculi


Tyzzer's disease

Whitewater Arroyo virus

Yersinia enterocolitica

Yersinia pestis

Yersinia pseudotuberculosis

Rabbit fibromavirus PCR test

rodent and rabbit assay data sheet

Rabbit fibroma virus

Test code: S0136 - Ultrasensitive qualitative detection of rabbit fibromavirus by real time PCR


Rabbit fibroma virus, also known as Shope fibroma virus or fibromatosis virus of rabbits, is a poxvirus of the genus leporipoxvirus and is closely related to vaccinia and myxoma viruses. Infection of rabbits with this virus can result in multiple small (25 mm diameter), firm, pinkish-red, spherical fibromas all over the body (Strayer et al., 1983).

Infections in rabbits have been reported in a number of states and are usually found on cottontail rabbits living east of the Mississippi River. In Michigan, cottontail rabbits in the southern Lower Peninsula are commonly infected.

The virus can be transmitted between cottontail rabbits through the bites of fleas, mosquitoes and possibly other biting insects. The resulting loosely attached tumors occur most frequently on the skin of the feet, nose, eyelids, lips, ears and back. The fibroma virus acts directly on epidermal and connective tissue cells, causing formation of a localized tumor. The tumor grows very slowly and will regress after 10 to 12 months when the body starts to develop antibodies.

Gross examination may be sufficient because the characteristic size, shape and appearance of the fibromas allow for a quick and fairly accurate presumptive diagnosis. However, to confirm the diagnosis molecular testing and/or histopathological examination should be performed.


  • Help confirm the disease causing agent
  • Shorten the time required to confirm a clinical diagnosis of rabbit fibroma virus
  • Help ensure that rabbit colonies or populations are free of this virus
  • Early prevention of spread of this virus among a population or in a geographic area
  • Minimize human exposure to this virus
  • Safety monitoring of biological products that derive from rabbits

Strayer, D.S., Cabirac, G., Sell, S. and Leibowitz, J.L. (1983) Malignant rabbit fibroma virus: observations on the culture and histopathologic characteristics of a new virus-induced rabbit tumor. J. Natl. Cancer Inst. 71:91-104

Specimen requirements: 0.2 ml tissue, or 0.2 ml whole blood in EDTA (purple top) tube.

Contact Zoologix if advice is needed to determine an appropriate specimen type for a specific diagnostic application. For specimen types not listed here, please contact Zoologix to confirm specimen acceptability and shipping instructions.

For all specimen types, if there will be a delay in shipping, or during very warm weather, refrigerate specimens until shipped and ship with a cold pack unless more stringent shipping requirements are specified. Frozen specimens should be shipped so as to remain frozen in transit. See shipping instructions for more information.

Turnaround time: 2 business days

Methodology: Qualitative real time polymerase chain reaction

Normal range: Nondetected

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