Screening your mice? Try our Mouse Essentials PCR Panel. All the most important mouse colony screening tests, all by expert real time PCR...

...or how about our new Mouse PCR Minipanel - PCR tests for only the most common mouse pathogens - for economical colony screening...

...and don't forget our Mouse Fecal PCR Panel - includes 9 important fecal pathogens.

And... just for rabbits: our new Rabbit Fecal PCR Panel tests for 3 common causes of GI problems in rabbits.

For wild rodent infestations, remediation and environmental monitoring, use our Rodent Infestation PCR Panel

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Zoologix also performs rodent and rabbit PCR tests for...

Aspiculuris tetraptera


BXV-1 virus



Clostridium piliforme


E. coli (enteroinvasive)



Encephalitozoon cuniculi


Francisella tularensis

Fur mites



Human adenoviruses

Klebsiella pneumoniae

K virus

Lactate dehydrogenase-elevating virus


Lymphocytic choriomeningitis virus (LCMV)


Mouse adenoviruses

Mouse cytomegaloviruses

Mouse hepatitis virus (MHV)

Mouse kidney parvovirus (MKV or MKPV)

Mouse minute virus (MMV)

Mouse norovirus (MNV)

Mouse parvovirus (MPV)

Mouse polyoma virus (POLY)

Mousepox virus (aka ectromelia virus, EV or ECTRO)

Mouse rotavirus

Mycoplasma pulmonis

Mycoplasma screen



Pneumocystis carinii

Pneumonia virus of mice (PVM)

Rabbit coronavirus

Rabbit fibroma virus

Rabbit hemorrhagic disease virus

Rat bite fever

Rat coronavirus

Reovirus screen

Reovirus type 3 (REO3)



Sendai virus (SEND)

Seoul virus


Sialodacryoadenitis virus (SDAV)

Streptobacillus moniliformis

Streptococcus pneumoniae

Syphacia muris

Syphacia obvelata

Theiler's murine encephalomyelitis virus (TMEV)

Tickborne encephalitis virus

Treponema cuniculi/ paraluiscuniculi


Tyzzer's disease

Whitewater Arroyo virus

Yersinia enterocolitica

Yersinia pestis

Yersinia pseudotuberculosis

Mouse norovirus PCR test

rodent and rabbit assay data sheet

Mouse norovirus (MNV)

Test code: S0138 - Ultrasensitive qualitative detection of mouse norovirus by reverse transcription coupled real time PCR

S0138 is included on P0023 - Mouse Fecal Panel, P0029 - Mouse Essentials Panel and P0032 Mouse Minipanel

Noroviruses are a group of genetically related and antigenically diverse viruses that can infect both humans and animals. They are caliciviruses and carry positive single-stranded RNA. These viruses are resistant to organic solvents and mild detergents and hence can survive in the environment for some time. Transmission occurs by ingestion of material contaminated by infected feces. These viruses infect and replicate in dendritic cells of the gut and in macrophage cells.

Mouse norovirus was first identified in 2003. Immunocompetent mice infected with the virus can develop transient infection with a short duration of fecal shedding of the virus. Mice that are immunocompromised, including some knockout strains, can develop lethal infection. Sharing of mice between animal facilities can significantly increase the risk of spreading the infection.

Serologic assays can be used to detect exposure of mice to the virus, but it usually takes a long time for detectable serological changes to occur.  However, even recently-infected mice will shed the virus in feces, allowing viral RNA to be readily detected by reverse transcription coupled real time PCR (Kelmenson et al., 2009).  PCR detection is highly sensitive, specific and rapid; this technique provides a valuable tool for screening mice being moved between facilities.


  • Help confirm the disease causing agent
  • Shorten the time required to confirm a clinical diagnosis of norovirus
  • Help ensure that vivariums are free of norovirus
  • Early prevention of spread of norovirus among a vivarium
  • Minimize personnel exposure to this virus
  • Safety monitoring of biological products that derive from mice

Kelmenson, J.A., Pomerleau, D.P., Griffey, S., Zhang, W., Karolak, M.J. and Fahey, J.R. (2009) Kinetics of transmission, infectivity, and genome stability of two novel mouse norovirus isolates in breeding mice. Comp. Med. 59:27-36

Specimen requirements: 1 fecal pellet, or 0.2 ml cell culture.

Contact Zoologix if advice is needed to determine an appropriate specimen type for a specific diagnostic application. For specimen types not listed here, please contact Zoologix to confirm specimen acceptability and shipping instructions.

For all specimen types, if there will be a delay in shipping, or during very warm weather, refrigerate specimens until shipped and ship with a cold pack unless more stringent shipping requirements are specified. Frozen specimens should be shipped so as to remain frozen in transit. See shipping instructions for more information.

Turnaround time: 2 business days

Methodology: Qualitative reverse transcription coupled real time polymerase chain reaction

Normal range: Nondetected

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