rodent and rabbit assay data sheet
Mouse kidney parvovirus
S0246 - Ultrasensitive qualitative detection of
mouse kidney parvovirus (MKV or MKPV) by
real time polymerase chain
Mouse kidney parvovirus (MKV or MKPV) is a recently discovered parvovirus
in mouse. It is also known as murine chapparvovirus (MuCPV). The
genetic sequence of this new strain of parvovirus is quite
different from that of more familiar mouse parvoviruses, such as
mouse parvovirus-1 and mouse minute virus. MKPV is a
single-stranded DNA parvovirus, only distantly related to other
known mouse parvoviruses; it is more similar to other members of
the provisional genus Chapparvovirus.
In immunodeficient mice, infection with MKV can result in severe chronic
interstitial nephropathy and renal failure within a few months.
For healthy mice, MKV infection can have a variable disease
course. Some infected mice may be asymptomatic and continue
shedding the virus through their feces and urine. Multiple
animal facilities around the world have reported infection of
their mice with this virus (Ge, Z. et al., 2020). Co-housing
with inapparent carrier MKV-infected mice is the major cause of
the spread of this virus.
Identification of this virus mainly relies on detecting the viral genome
using PCR, which is rapid and specific (Ge, Z. et al., 2020).
Help confirm the disease causing agent
Shorten the time required to confirm a clinical
diagnosis of MKPV infection
Help ensure that rodent colonies are free of this virus
Early prevention of spread of MKPV among a colony
Minimize human exposure to this virus
Safety monitoring of biological products that derive
Ge, Z., Carrasco, S.E., Feng, Y., Bakthavatchalu, V., Annamalai, D.,
Kramer, R., Muthupalani, S. and Fox, J.G. (2020) Identification
of a new strain of mouse kidney parvovirus associated with
inclusion body nephropathy in immunocompromised laboratory mice.
Emerg. Microbes Infect. 9:1814-1823.
Fecal pellet, or 0.2 ml EDTA whole blood, or 0.2 ml serum or
plasma or urine.
Contact Zoologix if advice is needed to determine an appropriate specimen type for a specific diagnostic application. For specimen types not listed here, please contact Zoologix to confirm specimen acceptability and shipping instructions.
specimen types, if there will be a delay in shipping, or during
very warm weather, refrigerate specimens until shipped and ship
with a cold pack unless more stringent shipping requirements are
specified. Frozen specimens should be shipped so as to remain
frozen in transit. See shipping
instructions for more information.
2 business days
real time PCR