dog and cat assay data sheet
Canine circovirus (CaCV)
S0234 - Ultrasensitive qualitative detection of canine circovirus by real time polymerase chain
S0234 is included
on P0022 - canine diarrhea panel
There are 11 known species of circoviruses and they affect many bird and
mammal species. Canine circovirus (CaCV or DogCV) is a member of
Circoviridae family, genus Circovirus and was first isolated in
2012. It is a small non-enveloped virus with a ~2 kb length
single-stranded DNA viral genome. Canine circovirus infects
domestic dogs and wild canids exclusively.
Dogs infected with this virus may develop hemorrhagic enteritis that
results in sudden onset of weakened appetite, vomiting, and
bloody diarrhea. Internally, infected dogs may develop
inflammation of the blood vessels and lymph node necrosis. The
virus can disseminate into various organs including intestines,
spleen, lungs, brain, liver, and lymph nodes.
Infected dogs have a high frequency of co-infection with other viruses,
such as canine distemper and canine parvovirus; thus, clinical
presentation when co-infection occurs may confuse the correct
The mode of transmission of this virus is still unknown. Direct contact
with an infected dog, its vomit or feces, is believed to
increase the risk of infection. The use of shared bedding and
equipment, or human contact with an infected animal prior to
handling of an uninfected animal, may also cause transmission of
the virus between dogs.
Diagnosis of the viral infection usually relies on molecular detection by
PCR, which gives high sensitivity and specificity.
Help confirm the disease causing agent
Help ensure that animal groups and populations are free of
Early prevention of spread of this virus among a
Minimize human exposure to this virus
Safety monitoring of biological products and vaccines
that derive from susceptible animals
Niu, L., Wang, Z., Zhao, L., Wang, Y., Cui, X., Shi, Y., Chen, H. and Ge,
J. (2020) Detection and molecular characterization of canine
circovirus circulating in northeastern China during 2014-2016.
Arch. Virol. 2020 165:137-143.
0.2 ml feces, or fecal swab, or 0.2 ml whole blood in EDTA
(purple top) tube,
or 0.2 ml fresh or frozen tissue, or 0.2 ml culture.
Contact Zoologix if advice is needed to determine an appropriate specimen type for a specific diagnostic application. For specimen types not listed here, please contact Zoologix to confirm specimen acceptability and shipping instructions.
specimen types, if there will be a delay in shipping, or during
very warm weather, refrigerate specimens until shipped and ship
with a cold pack unless more stringent shipping requirements are
specified. Frozen specimens should be shipped so as to remain
frozen in transit. See shipping
instructions for more information.
2 business days
Qualitative real time PCR