Herpesvirus papio 1 and 2 (HVP-1 and HVP-2)
- Qualitative detection of herpesvirus papio 1 (HVP-1) by
polymerase chain reaction
- Qualitative detection of herpesvirus papio 2 (HVP-2) by
polymerase chain reaction
baboons with herpesvirus papio 2 (HVP-2) produces a disease that
is similar to human infection with herpes simplex viruses (HSV).
HVP-2 infection is associated with oral and genital lesions that
resemble HSV infections of humans. Male baboons develop erythema
of the penis with papules or pustules that develop into small
ulcerative lesions. Female baboons have been observed with
ulcerative lesions on the vulvar tissues. Juvenile animals were
found to have primarily oral lesions. Acquisition of genital
infection is primarily associated with the onset of sexual
activity in baboons. Furthermore, one study provided evidence
that the virus could spontaneously reactivate from latency, a
pattern consistent with HSV infection of humans.
analysis has determined that over 90% of wild-caught baboons
were found to have anti-HVP-2 titers, confirming that baboons
are a natural host for HVP-2. However, it is not clear what
percentage of them are active carriers of this virus.
virus isolation can be used to diagnose HVP-2 virus infection
and determine carrier status, a long incubation period is
required to obtain results. Viral culture also increases the
potential risk of laboratory personnel contacting this virus.
Furthermore, viral culture is not as sensitive or specific as
PCR-based techniques. Serological testing for HVP-2 antigens is
difficult because of the close antigenic relation between
surface antigens among the alphaherpesviruses. HVP-2 detection
by PCR is the most rapid, sensitive and specific method for the
diagnosis of this infection and confirmation of the carrier
status of the animal.
Help confirm the disease causing agent
Help ensure that animal colonies are free of HVP-1 and HVP-2
Early prevention of spread of these viruses among a
Minimize personnel exposure to these viruses
Safety monitoring of biological products and vaccines
that derive from primates
Lesion swab, or 0.2 ml whole blood in EDTA (purple top) or ACD (yellow top)
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specimen types, if there will be a delay in shipping, or during
very warm weather, refrigerate specimens until shipped and ship
with a cold pack unless more stringent shipping requirements are
specified. Frozen specimens should be shipped so as to remain
frozen in transit. See shipping
instructions for more information.
2 business days