equine assay data sheet
Equine parvovirus (EqPV-H)
code: S0232 - Ultrasensitive
qualitative detection of equine
parvovirus-hepatitis virus (EqPV-H) by TaqMan real time PCR.
Recent research studies have linked the administration of an equine
biologic product, such as tetanus antitoxin or equine plasma, to
equine serum hepatitis (Theiler’s disease or idiopathic acute
hepatitis) (Divers et al., 2018). Detailed analysis suggests the
association of equine parvovirus-hepatitis (EqPV-H) with
contamination of these biological products leading to equine
EqPV-H is hepatotropic and pathogenic but the great majority of recently
infected horses develop only subclinical symptoms, mostly with
only elevated serum liver enzymes for a few weeks. However, in
clinically affected horses that show signs of lethargy,
anorexia, jaundice, or neurologic symptoms, the mortality rate
is almost 50%. About 1-2% of EqPV-H infected horses show these
EqPV-H is genetically more related to other ungulate copiparvoviruses
than another recently identified equine copiparvovirus known as
In an attempt to eliminate the risk of equine serum hepatitis secondary
to equine biologic product administration, equine-derived
biological products may need to be tested for EqPV-H.
Currently, detection of this virus by viral culture is not
practical. Molecular detection by PCR is a
sensitive and rapid method to identify the presence of this
Confirm the disease causing agent
Shorten the time required to confirm a clinical
diagnosis of the presence of these viruses
Ensure that horse populations are free of these viruses
Early prevention of spread of these viruses
Minimize human exposure to these viruses
Safety monitoring of biological products that derive
Divers, T. J., Tennant, B. C., Kumar, A., McDonough, S., Cullen, J.,
Bhuva, N....Kapoor, A. (2018). New Parvovirus Associated with
Serum Hepatitis in Horses after Inoculation of Common Biological
Product. Emerging Infectious Diseases, 24(2), 303-310.
Specimen requirements: 0.2 ml whole blood in EDTA (purple top) or ACD (yellow top)
tube; or 0.2 ml serum; or 0.2 ml fresh or frozen
tissue; or 0.2 ml culture.
Contact Zoologix if advice is needed to determine an appropriate specimen type for a specific diagnostic application. For specimen types not listed here, please contact Zoologix to confirm specimen acceptability and shipping instructions.
specimen types, if there will be a delay in shipping, or during
very warm weather, refrigerate specimens until shipped and ship
with a cold pack unless more stringent shipping requirements are
specified. Frozen specimens should be shipped so as to remain
frozen in transit. See shipping
instructions for more information.
2 business days
TaqMan real time PCR