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Zoologix performs avian and livestock PCR tests for...

Actinobacillus pleuropneumoniae

African swine fever

Akabane virus

Alcelaphine herpesvirus

AMPKγ3R200Q mutation in pigs

Anaplasma phagocytophilum

Aspergillus fumigatus

Aspergillus species


Avian adenovirus

Avian herpes

Avian influenza

Avian polyomavirus

Avian reovirus

Baylisascaris procyonis

Blood typing for swine

Bluetongue virus

Bordetella avium

Borna virus

Bovine adenovirus

Bovine endogenous retrovirus

Bovine enterovirus

Bovine ephemeral fever virus

Bovine herpesvirus 1

Bovine herpesvirus 2

Bovine herpesvirus 4

Bovine leukemia virus

Bovine papillomavirus

Bovine papular stomatitis virus

Bovine parvovirus

Bovine polyomavirus

Bovine respiratory syncytial virus

Bovine rhinoviruses

Bovine viral diarrhea

Brachyspira pilosicoli


Cache Valley virus




Caprine arthritis-encephalitis (CAE) virus

Chlamydophila psittaci

Classical swine fever






Coxiella burnetii



E. coli O157:h7



Enteric E. coli panel

Erysipelothrix rhusiopathiae

Foot and mouth disease


Fusobacterium necrophorum

Hepatitis E

Herpes, avian


Infectious bronchitis

Infectious bursal disease

Infectious coryza

Infectious laryngotracheitis


Jaagsiekte sheep retrovirus (JSRV)

Japanese encephalitis

Jena virus

Johne's disease


Lumpy skin disease virus


Malignant catarrhal fever (MCF)

Malignant hyperthermia in pigs


Mycobacterium avium and other Mycobacteria

Mycoplasma species

Mycoplasma suis

Newcastle disease virus

Nipah virus

Ornithobacterium rhinotracheale

Ovine herpesvirus 2

Pacheco's disease (psittacid herpesviruses)

Peste des petits ruminants virus (PPRV)

Pigeon circovirus

Plasmodium species

Porcine adenovirus

Porcine circovirus 1

Porcine circovirus 2

Porcine cytomegalovirus

Porcine endogenous retrovirus (PERV)

Porcine enterovirus

Porcine epidemic diarrhea virus

Porcine hemagglutinating encephalomyelitis

Porcine lymphotropic herpesvirus

Porcine parvovirus

Porcine reproductive & respiratory syndrome (PRRS) virus

Porcine respiratory coronavirus (PRCV)

Porcine transmissible gastroenteritis virus (TGEV)

Poultry respiratory panel



Psittacine beak and feather disease

Psittacine herpes

Q fever



Rift Valley fever virus

Rinderpest virus

RyR1 R615C mutation in pigs


Staphylococcus xylosus

St. Louis encephalitis


Swine malignant hyperthermia


Swine vesicular disease

Teschovirus (Teschen-Talfan disease)

Tickborne encephalitis virus



Valley fever

Vesicular exanthema of swine

Vesicular stomatitis

Wesselsbron virus

West Nile virus

Yersinia enterocolitica

Yersinia pseudotuberculosis

...and more -- see the avian & livestock test menu for a complete listing of avian and livestock assays.

jaagsiekte sheep retrovirus PCR test
avian & livestock assay data sheet

Jaagsiekte sheep retrovirus (JSRV)

Test code: S0201
- Ultrasensitive qualitative detection of jaagsiekte sheep retrovirus proviral DNA by real time PCR.

Infection of sheep by jaagsiekte sheep retrovirus (JSRV) can result in ovine pulmonary adenocarcinoma (OPA), a contagious cancer. The disease was initially described in 1915 in South Africa and was subsequently found to be present worldwide. JSRV is a betaretrovirus, within the Retroviridae family.

This virus is transmitted between animals by close contact, mainly through aerosolized particles. Close breeding conditions are of major importance for the dissemination of the virus. Infected animals may take 2 to 4 years to develop the full spectrum of symptoms, but in some cases, the cancer may be diagnosed as early as a few months after birth. The onset of the disease seems to be age-dependent. Thus, animals may be carriers of the virus without symptoms and become potential viral reservoirs.

JSRV is phylogenetically related to the enzootic nasal tumor virus (ENTV) which is responsible for nasal adenocarcinoma, a contagious tumor of the nasal mucosa affecting sheep and goats. In ENTV-infected animals, epithelial cell proliferation causes continuous nasal discharge, respiratory distress, exophthalmos and skull deformations. Co-infection of ENTV and JSRV has been reported.

Detection of JSRV in sheep is complicated by the fact that a family of endogenous retroviruses, enJSRV (endogenous JSRV) closely related to JSRV, is present in the genomes of domestic and wild sheep and goats. JSRV and enJSRV genomes are highly similar with 90–98% homology in deduced amino-acid sequences. Endogenous retroviruses are vertically transmitted as stable Mendelian genes in the germline of most eukaryotes. These endogenous retroviral sequences derive from the integration of exogenous viruses into host genomes, followed by genetic stabilization through accumulation of mutations. These endogenous retroviral sequences are not active and their significance is not clear. However, their similarity to exogenous viral sequences is a factor in the design of PCR primers for detecting JSRV in these host species.

Currently, good serological methods to detect JSRV are not available. Molecular detection by PCR is the most important tool to screen animals for infection by this virus (Zhang et al., 2014).


  • Help confirm the disease causing agent
  • Identify JSRV carriers
  • Screen research materials for the presence of JSRV
  • Help ensure that animal groups are free of JSRV
  • Early prevention of spread of the virus among animals
  • Minimize human exposure to the virus
  • Safety monitoring of biological products that derive from susceptible animals

Zhang, K., Kong, H., Liu, Y., Shang, Y., Wu, B. and Liu, X. (2014) Diagnosis and phylogenetic analysis of ovine pulmonary adenocarcinoma in China. Virus Genes, 48:64–73.

Specimen requirements: Nasal swabs, or 0.2 ml whole blood in EDTA (purple top) or ACD (yellow top) tube, or 0.2 ml fresh, frozen or fixed tissue.

Contact Zoologix if advice is needed to determine an appropriate specimen type for a specific diagnostic application. For specimen types not listed here, please contact Zoologix to confirm specimen acceptability and shipping instructions.

For all specimen types, if there will be a delay in shipping, or during very warm weather, refrigerate specimens until shipped and ship with a cold pack unless more stringent shipping requirements are specified. Frozen specimens should be shipped so as to remain frozen in transit. See shipping instructions for more information.

Turnaround time: 2 business days

Methodology: Qualitative real time PCR

Normal range: Nondetected

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